PHP regex strip coma and space from beginning and end of string

I have some strings like this

", One "
", One , Two"
"One, Two "
" One,Two, "
" ,Two ,Three "

and need to remove space and or coma at beginning and end of string only tried few regex with preg_replace(), but they replace all occurrences.

EDIT: Actually would be great to remove all clutter like !@#$%^&*( etc whatever is at the end and beginning of string, but not in between.

Optionally need to make strings look proper by placing word then coma then space then another word (if there's coma one in between words).

Example "One,Two ,Three , Four" into "One, Two, Three, Four".

P.S. Please provide answer as two separate regex as its easier to understand.